MacKenzie's Pharmacy is changing names after 80 years in business.
The owner, who declined to identify himself, also declined to discuss details of the change, but said he would be staying on and all customer files would transferred to CVS.
"I will still be here," he said. "We will still be here."
The owner urged all customers to pick up prescriptions before 5 p.m. Friday. Otherwise, they will have to be returned.
Several other mom-and-pop businesses are closing or have closed in Trumbull Center, for various reasons. France's Bakery, Trumbull Aquarium and Porricelli's have all shut down since last year, and a mailbox store moved across the street.
Some of the remaining local businesses include a Japanese and a Chinese restaurant, Sapore Deli, Aliette Monjoux (hair salon) and Head Company Hair Wizards.
The shopping plaza also contains chain stores such as Bruegger's Bagels and Starbucks.
Meanwhile, Marie's Sandwich Shop, a neighbor of the pharmacy, closes sometime this week, after nearly 50 years in business.
Marie's owner of seven years, Kathleen Hallahan, said MacKenzie's "has been a great neighbor."
The nearest CVS stores to Trumbull are on East Main Street and Main Street, Bridgeport; Hawley Lane in Stratford, across from the Hawley Lane Mall; and in the Big Y Plaza on Route 111 in Monroe.